A thousand and two protein tyrosine phosphatases.
نویسندگان
چکیده
!. Introducti~ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35 II. ~ l a r gMology of tim PTPases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36 I l L Structure and function studies of the PTPases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38 IV. Bio~gy of the PTPases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40 V. Concluding remarks ......................................................... 42 Acknowledgements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42
منابع مشابه
Regional Assignment of Ptpre Encoding Protein Tyrosine Phosphataes ε to Mouse Chromosome 7F3
Protein tyrosine phosphatases (PTPases) regulate the tyrosine phosphorylation of target proteins involved in several biological activities including cell proliferation and transformation. Protein tyrosine phosphatase E (PTPE) contains duplicated PTPase-like domains and a short extracellular region. Using the fluorescence in situ hybridization method, the gene encoding PTPE (locus symbol Ptpre...
متن کاملRole of adenosine receptors and protein phosphatases in the reversal of pentylenetetrazol-induced potentiation phenomenon by theta pulse stimulation in the CA1 region of rat hippocampal slices
The effect of theta pulse stimulation (TPS) on pentylenetetrazol (PTZ)-induced long-term potentiation of population spikes (PS) was studied in the hippocampal CA1 in vitro. A transient PTZ application produced a long-lasting enhancement of PS amplitude. A 3-min episode of TPS delivered at a higher intensity produced complete reversal of the PTZ potentiation when delivered during the last minute...
متن کاملReversible Inhibition of Tyrosine Protein Phosphatases by Redox Reactions
Protein phosphorylation/dephosphorylation is considered a widespread mechanism of protein regulation. The covalent addition of a phosphate group to tyrosine residues in cellular proteins may occur as an appropriate response to a series of morphological and biochemical processes, with particular importance in complex functions such as growth, proliferation, differentiation, adhesion and motility...
متن کاملThe Structure and Topology of Protein Serine/Threonine Phosphatases
Structural studies of the two families of protein phosphatases responsible for dephosphorylating serine and threonine residues have revealed that, although these families are unrelated in sequence, the architecture of their catalytic domains is remarkably similar and distinct from the protein tyrosine phosphatases. The diversity of structure within the PPP and PPM families is generated by regul...
متن کاملSecondary structure prediction from multiple sequence data: blood clotting factor XIII and Yersinia protein-tyrosine phosphatase.
Predictions of protein structure are best tested without prior knowledge of the protein three-dimensional structure. Three-dimensional atomic models will soon be determined by X-ray crystallography for the alpha-subunit of human blood clotting factor XIII and members of the family of protein tyrosine specific phosphatases. Accordingly, we here present secondary structure predictions for each of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Biochimica et biophysica acta
دوره 1136 1 شماره
صفحات -
تاریخ انتشار 1992